977 Outcomes of intrahepatic cholestasis of pregnancy in women with a prior cholecystectomy

Intrahepatic cholestasis of pregnancy (ICP) is characterized by pruritus in the setting elevated serum bile acids (BA). While some studies have identified cholecystectomy (CCY) as a risk factor for developing ICP, little known about effects prior CCY on severity or outcomes disease. Our objective was to compare maternal women with and without who developed ICP. This retrospective cohort study patients diagnosed ICP between 2012 2019 at tertiary referral center. defined symptomatic combined BA ?10 ?mol/L. Maternal characteristics were abstracted from electronic medical records compared those CCY. Student’s t-test, Mann-Whitney U, Chi-squared Fisher’s exact tests used appropriate. A p-value < 0.05 considered statistically significant. 438 included analysis. Women shared similar baseline including age, race, gestational age diagnosis. more likely severe disease (BA ?100 ?mol/L, 12% vs 2%, p<0.01) despite no difference history cesarean section, delivery (43% 28%, p=0.04). There trend AST CCY, though this not significant (45% 31%, p=0.05). incidence diabetes, hypertensive disorders pregnancies, fetal growth restriction, preterm labor two groups. also composite adverse neonatal (33 29%, p=0.48). are delivery. Serial acid measurements evaluate development may be warranted population.View Large Image Figure ViewerDownload Hi-res image Download (PPT)